The Sports Wire

Lions at Bills

Prediction updated
Lions at Bills · Week 2 · Thu, Sep 17 · 7:15 PM CT · Prime Video

Our call: BillsLean

5 of 5 models favor the Bills.

On average the models have the Bills by 3.6 points, a 62% win chance.

Final: Bills 41, Lions 31.

Closest of our models: ESPN FPI (Bills by 4.5, missed by 5.5). 5 of 5 models named the winner.

Our call was right.

Reconstructed: Week 2 came before these pages existed, so every number here was worked out afterwards from data before the week, the same way as a live week (ESPN's FPI is the pre-game number ESPN still keeps). The scorecard keeps reconstructed weeks apart.

Data through Week 5's games (the last played Mon, Oct 12), from nflverse play-by-play; nflverse last published it .

Detroit Lions (1–0) at Buffalo Bills (1–0) Thu, Sep 17, 2026 Kickoff 7:15 PM CT on Prime Video Buffalo

TV listings: ESPN

After the game

The Bills won 41–31. Allen threw for 248 yards and 3 touchdowns. Our call (Bills, Lean) was right.

Leaders

Passing: completions-attempts, yards. Rushing: carries-yards. Receiving: catches-yards.

Team statsLionsBills
Yards gained355446
Passing yards289243
Rushing yards66203
Sacked4 (38 yards)2 (5 yards)
Interceptions thrown00

Detroit Lions

Buffalo Bills

From nflverse's player stats, published the morning after the game: each team's numbers are its players' lines added up, and passing yards are net of the yards lost to sacks, as the NFL counts them.

Every model

ModelSaysWin chanceMissed by
Consensus (our call)The average of Our model, Elo, SRS and ESPN FPI (whichever are there); the market is left out. This is our call.Bills by 3.6 ✓62%6.4
Our model ExperimentalOur ratings from nflverse play-by-play: opponent-adjusted EPA per play, home field and the starting quarterback, frozen on the 2024 season and tested once on 2025. Experimental.Bills by 3.4 ✓60%6.6
EloEvery team's Elo rating from every game since 1999 (FiveThirtyEight's method).Bills by 4.2 ✓65%5.8
SRSSimple Rating System: points scored minus allowed, adjusted for the schedule, blended with last season early on. Settings chosen by hand, not tuned.Bills by 2.4 ✓57%7.6
ESPN FPI ClosestESPN's Football Power Index matchup predictor, read from ESPN before kickoff.Bills by 4.5 ✓67%5.5
RecordThe team with the better record this season; equal records go to the home team. A winner only.Bills ✓——
MarketThe market's margin, shown for comparison only: never a win chance, and not in our call.Bills by 5.5—4.5

Our model is experimental. Season so far (79 games, Weeks 1–4 reconstructed): it missed the final margin by 9.8 points on average, the market's margin by 9.8; ours was closer in 38 of 79. Scorecard →

Starting quarterbacks assumed

Injuries

The official Week 2 injury report as on file Mon, Oct 5 · 10:53 AM CT, saved after the fact like the rest of this reconstructed week: game status and practice status. Players with a game status or a missed or limited practice.

Lions

  • Blake Miller T · Knee · practice: Did not practiceOut
  • Christian Mahogany G · Hip · practice: Did not practiceOut
  • D.J. Reed CB · Foot · practice: LimitedQuestionable

Bills

  • Ty Johnson RB · Hamstring · practice: LimitedQuestionable
  • T.J. Sanders DE · Knee · practice: LimitedQuestionable
  • Cole Bishop S · Knee · practice: LimitedQuestionable
  • Terrel Bernard LB · practice: Limited—

Matchup

Opponent-adjusted, from nflverse play-by-play, through the games before Week 2; league rank in brackets.

LionsBills
Net EPA per play0.00 (15th)+0.04 (8th)
Offense, EPA per play+0.01 (16th)+0.07 (5th)
Defense, EPA per play allowed (lower is better)+0.01 (15th)+0.03 (20th)
Passing offense, EPA per dropback+0.04 (19th)+0.18 (4th)
Rushing offense, EPA per run−0.04 (14th)−0.09 (27th)
Offense success rate45% (13th)44% (23rd)

Last 5 meetings

The Bills won 5 of the last 5 meetings.

Dec 15, 2024Week 15, 2024Bills 48, Lions 42at Detroit
Nov 24, 2022Week 12, 2022Bills 28, Lions 25at Detroit
Dec 16, 2018Week 15, 2018Bills 14, Lions 13at Buffalo
Oct 5, 2014Week 5, 2014Bills 17, Lions 14at Detroit
Nov 14, 2010Week 10, 2010Bills 14, Lions 12at Buffalo