The Sports Wire

Cardinals at 49ers

Prediction updated
Cardinals at 49ers · Week 3 · Sun, Sep 27 · 3:05 PM CT · Fox

Our call: 49ersStrong

5 of 5 models favor the 49ers.

On average the models have the 49ers by 9.9 points, a 79% win chance.

Final: 49ers 36, Cardinals 30.

Closest: Our model (49ers by 6.5, missed by 0.5). 5 of 5 models named the winner.

Our call was right.

Reconstructed: Week 3 came before these pages existed, so every number here was worked out afterwards from data before the week, the same way as a live week (ESPN's FPI is the pre-game number ESPN still keeps). The scorecard keeps reconstructed weeks apart.

Data through Week 5's games (the last played Mon, Oct 12), from nflverse play-by-play; nflverse last published it .

Arizona Cardinals (1–1) at San Francisco 49ers (2–0) Sun, Sep 27, 2026 Kickoff 3:05 PM CT on Fox San Francisco

TV listings: ESPN

After the game

The 49ers won 36–30. Purdy threw for 297 yards and 4 touchdowns. Our call (49ers, Strong) was right.

Leaders

Passing: completions-attempts, yards. Rushing: carries-yards. Receiving: catches-yards.

Team statsCardinals49ers
Yards gained365437
Passing yards272297
Rushing yards93140
Sacked2 (8 yards)0
Interceptions thrown00

Arizona Cardinals

San Francisco 49ers

  • PassingBrock Purdy: 15 of 27 for 297 yards, 4 touchdowns
  • RushingChristian McCaffrey: 15 carries for 75 yards, 1 touchdown
  • ReceivingGeorge Kittle: 6 catches for 82 yards, 2 touchdowns
  • TacklesFred Warner: 17 tackles (8 solo)
  • SacksKeion White and Ogbo Okoronkwo: 1 sack each

From nflverse's player stats, published the morning after the game: each team's numbers are its players' lines added up, and passing yards are net of the yards lost to sacks, as the NFL counts them.

Every model

ModelSaysWin chanceMissed by
Consensus (our call)The average of Our model, Elo, SRS and ESPN FPI (whichever are there); the market is left out. This is our call.49ers by 9.9 ✓79%3.9
Our model Experimental ClosestOur ratings from nflverse play-by-play: opponent-adjusted EPA per play, home field and the starting quarterback, frozen on the 2024 season and tested once on 2025. Experimental.49ers by 6.5 ✓69%0.5
EloEvery team's Elo rating from every game since 1999 (FiveThirtyEight's method).49ers by 9 ✓79%3.0
SRSSimple Rating System: points scored minus allowed, adjusted for the schedule, blended with last season early on. Settings chosen by hand, not tuned.49ers by 10.4 ✓78%4.4
ESPN FPIESPN's Football Power Index matchup predictor, read from ESPN before kickoff.49ers by 13.7 ✓90%7.7
RecordThe team with the better record this season; equal records go to the home team. A winner only.49ers ✓——
MarketThe market's margin, shown for comparison only: never a win chance, and not in our call.49ers by 7.5—1.5

Our model is experimental. Season so far (79 games, Weeks 1–4 reconstructed): it missed the final margin by 9.8 points on average, the market's margin by 9.8; ours was closer in 38 of 79. Scorecard →

Starting quarterbacks assumed

Injuries

The official Week 3 injury report as on file Mon, Oct 5 · 10:53 AM CT, saved after the fact like the rest of this reconstructed week: game status and practice status. Players with a game status or a missed or limited practice.

Cardinals

  • Dadrion Taylor-Demerson S · Back · practice: Did not practiceOut
  • Roy Lopez DT · Groin · practice: LimitedQuestionable
  • Max Melton CB · Toe · practice: LimitedQuestionable

49ers

  • Demarcus Robinson WR · Ankle · practice: Did not practiceOut
  • Nick Bosa DE · Knee · practice: Did not practiceOut
  • Romello Height DE · Hand · practice: Did not practiceOut
  • James Thompson Jr. DT · Ankle · practice: Did not practiceOut
  • Mike Evans WR · Hip · practice: LimitedQuestionable

Matchup

Opponent-adjusted, from nflverse play-by-play, through the games before Week 3; league rank in brackets.

Cardinals49ers
Net EPA per play0.00 (16th)+0.21 (1st)
Offense, EPA per play−0.01 (20th)+0.16 (2nd)
Defense, EPA per play allowed (lower is better)−0.01 (14th)−0.06 (8th)
Passing offense, EPA per dropback+0.04 (21st)+0.32 (1st)
Rushing offense, EPA per run−0.10 (12th)−0.07 (9th)
Offense success rate43% (18th)50% (1st)

Last 5 meetings

The 49ers won 3 of the last 5 meetings.

Nov 16, 2025Week 11, 202549ers 41, Cardinals 22at Arizona
Sep 21, 2025Week 3, 202549ers 16, Cardinals 15at San Francisco
Jan 5, 2025Week 18, 2024Cardinals 47, 49ers 24at Arizona
Oct 6, 2024Week 5, 2024Cardinals 24, 49ers 23at San Francisco
Dec 17, 2023Week 15, 202349ers 45, Cardinals 29at Arizona